IS T228A POLYMORPHISM INSORBS1GENE ASSOCIATED WITH T2DM, GESTATIONAL DIABETES OR OBESITY IN LIBYAN PREGNANT WOMEN
GLUT4 translocation in response to insulin involves the PI3K/Akt
pathway and IR mediated phosphorylation of CAP (SORBS1), and
formation of the CAP:Cbl. These pathways act in a coordinated
manner to regulate glucose, lipid and protein metabolism. In previous
studies, T228A polymorphism of SORBS1 gene has been shown to be a protective factor for obesity, type-2 diabetes mellitus (T2DM),
polycystic ovary (PCOs), and lacunars infarction.
Objectives: The objective of this study was to investigate the
association between this polymorphism and T2DM, gestational
diabetes (GDM), and obesity.
Methods: Genotyping was achieved by PCR-RELP in 227 individuals
chosen randomly from the out patient’s clinics of Al-Jala maternity
hospital of Tripoli and Gharian hospital, including: 63 T2DM
patients, 59 GDM patients, 57 obese, 47 healthy control individuals
from Libyan pregnant women population (North-West Region).
Results: The results revealed that this polymorphism has no
association with T2DM, GDM, and obesity in comparison with the
control sample.
Conclusion: T228A polymorphism of SORBS1 gene is not associated
with the pathological conditions studied. arabic 15 English 98
Abdulla Bashein(1-2013)
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