GLUT4 translocation in response to insulin involves the PI3K/Akt pathway and IR mediated phosphorylation of CAP (SORBS1), and formation of the CAP:Cbl. These pathways act in a coordinated manner to regulate glucose, lipid and protein metabolism. In previous studies, T228A polymorphism of SORBS1 gene has been shown to be a protective factor for obesity, type-2 diabetes mellitus (T2DM), polycystic ovary (PCOs), and lacunars infarction. Objectives: The objective of this study was to investigate the association between this polymorphism and T2DM, gestational diabetes (GDM), and obesity. Methods: Genotyping was achieved by PCR-RELP in 227 individuals chosen randomly from the out patient’s clinics of Al-Jala maternity hospital of Tripoli and Gharian hospital, including: 63 T2DM patients, 59 GDM patients, 57 obese, 47 healthy control individuals from Libyan pregnant women population (North-West Region). Results: The results revealed that this polymorphism has no association with T2DM, GDM, and obesity in comparison with the control sample. Conclusion: T228A polymorphism of SORBS1 gene is not associated with the pathological conditions studied. arabic 15 English 98
Abdulla Bashein(1-2013)

Introduction: Extended-spectrum β-lactamases (ESBLs), including the AmpC type, are important mechanisms of resistance among Klebsiella pneumoniae and Escherichia coli isolates. Objective: The aim of the study was to investigate the occurrence of AmpC-type β-lactamase producers isolated from two hospitals in Tripoli, Libya. Methods: All clinical isolates (76 K. pneumoniae and 75 E. coli) collected over two years (2013-2014) were evaluated for susceptibility to a panel of antimicrobials and were analyzed phenotypically for the ESBL and AmpC phenotype using E-test and ESBL and AmpC screen disc test. Both ESBL and AmpC-positive isolates were then screened for the presence of genes encoding plasmid-mediated AmpC β-lactamases by polymerase chain reaction (PCR). Results: Of the K. pneumoniae and E. coli tested, 75% and 16% were resistant to gentamicin, 74% and 1.3% to imipenem, 71% and 12% to cefoxitin, 80% and 12% to cefepime, 69% and 22.6% to ciprofloxacin, respectively. None of the E. coli isolates were multidrug resistant compared with K. pneumoniae (65.8%). K. pneumoniae ESBL producers were significantly higher (85.5%) compared with (17.3%) E. coli isolates (P
Abdulaziz Zorgani, Abdulla Bashein(1-2017)

The Coronavirus Disease 2019 (COVID-19) pandemic has caused an unprecedented disruption in medical education and healthcare systems worldwide. The disease can cause life-threatening conditions and it presents challenges for medical education, as instructors must deliver lectures safely, while ensuring the integrity and continuity of the medical education process. It is therefore important to assess the usability of online learning methods, and to determine their feasibility and adequacy for medical students. We aimed to provide an overview of the situation experienced by medical students during the COVID-19 pandemic, and to determine the knowledge, attitudes, and practices of medical students regarding electronic medical education. A cross-sectional survey was conducted with medical students from more than 13 medical schools in Libya. A paper-based and online survey was conducted using email and social media. The survey requested demographic and socioeconomic information, as well as information related to medical online learning and electronic devices; medical education status during the COVID-19 pandemic; mental health assessments; and e-learning knowledge, attitudes, and practices. A total of 3,348 valid questionnaires were retrieved. Most respondents (64.7%) disagreed that e-learning could be implemented easily in Libya. While 54.1% of the respondents agreed that interactive discussion is achievable by means of e-learning. However, only 21.1% agreed that e-learning could be used for clinical aspects, as compared with 54.8% who disagreed with this statement and 24% who were neutral. Only 27.7% of the … arabic 23 English 116
Ahmed Alsoufi, Ahmed Zaid(1-2020)