Abstract Overall equipment effectiveness (OEE) is a well-accepted measure of performance in industry. In this thesis, the components of OEE were calculated over a period of 28 months using failure and repair data gathered from food and beverages packaging line. The failure and repair data of the packaging line were statistically analyzed to understand the nature of the failure patterns, and to estimate the reliability and maintainability characteristics of the packaging line in precise quantitative terms, moreover, the best fit distribution for TBF and TTR based on failure data were computed, these distributions were included in the simulation model to describe the reliability behavior of the packaging line. Among the techniques to tackle maintenance and reliability issues, simulation can undoubtedly play an important role as it provides what-if analysis and hence help to evaluate quantitative benefits. This thesis also describes the modelling of machine breakdown behavior in industrial machines, a packaging line machines in the Aseptic Liquid Food (ALF) factory. The model also examines three important scheduled tasks (parameters) influence on packaging machines to study the correlation between these parameters and the occurrence of breakdown. Results show that the component Availability of the OEE metric should be improved to optimise the productivity and the efficiency of the line. the model results of failure time metrics (i.e. MTBF and MTTR) were validated using Output Analyzer template within Arena simulation software; and the results were near actual figures of collected data. The results of second experiment model showed a decrease in breakdown occurrences compared to first experiment, however, the scheduled tasks usage rate didn't correlate to breakdown occurrences, indicating the need to study and analyze different possible reasons of breakdown occurrence. Keywords: TPM, WCM, OEE, Simulation and modelling
Tajedeen Ramadan Own(1-2022)

Abstract The pharmacokinetics and absolute bioavailabilities of two generic formulations of enrofloxacin (ENRO- A; Enrol®: Medmac®, Amman, Jordan and ENRO- B; Syvaquinol® Syva®, Leon, Spain) 10% oral solutions were compared after single intracrop (i.c.) bolus administrations in reference to single intravenous bolus (i.v.) administration of standard ENRO at a dose of 10 mg/Kg body weight in broilers using a randomized parallel design. Plasma collected at predetermined time points up to 24 hours. Clinicochemical, hematological and histopathological alterations were also, demonstrated after repeated intracrop (i.c.) bolus administrations of the two different enrofloxacin generic preparations given at a dose regimen of 10 mg/Kg body weight for 5 consecutive days in ENRO-A and ENRO-B treated groups whereas control group was kept untreated and given water instead. Blood samples were collected from all birds on the 5th day for clinicochemical and hematological examinations. Birds were then humanely sacrificed liver, kidneys and heart were dissected out for histopathological examination. HPLC assay was used to measure concentrations of ENRO in plasma. The pharmacokinetic analysis of the C-T data was performed using non-compartmental analysis based on statistical moment theory. The maximum plasma concentrations (Cmax) for ENRO-A and ENRO-B were 1.61 ± 0.203 and 1.79 ± 0.283 μg/mL; respectively, attained at time to peak (Tmax) of 2 h. Elimination half- lives (T1/2β) were 8.391 ± 0.312 and 8.458 ± 0.906 h, respectively. While areas under plasma concentration-time curves (AUC0→∞), and systemic bioavailabilities (F %) were 12.744 ± 2.951 and 14.354 ± 2.85 mg.h/L; and 78.96 ± 6.728 and 88.94 ± 10.89 % for ENRO-A and ENRO-B; respectively. Results of safety study revealed that ENRO-A induced a significant (p
ناصــر الطـاهـــر احويـسج(1-2016)

المقــــــ دمـــــــــــــة كككرّ ح ، كككّ ل نك والصكككل واللككلا هككك أشكككللها ال للهلككه ن ع ، ال ككك ّ ع لله ُ الح ككر . ا.وع ر ّ الله ه و ه آل وصحع وله ّصه صأ فأ تألله خ الأر ك ، أ خ ، فإنش لهش لله ال للهعأ غعن الإللا كنّ ّ ذلك لأ الق ككأ الشكك، خأ التككأ وصككن إل لكك، فككأ ليتكك و و تكك لأ كك ت كك،ون حقعككأ ل ككأ فككأ أرع كك، ال للهعأ صولله ال ّ . غرو لهش اللهي ه لله ، ك وغر ل هت ةذه ال ال ح ن إلكك ةككذا ، ي ككر العكك ّ حأ ا تككر ، ل عكك ةككذا الشكك لله ككن للهو ككأ وفصكك ،تكك ، ول كك التكككالله الءكككخا ع،لعحككك والت حككك وال شكككا والإع، كككأ ع، تعككك،للهه عككك للهوت ككك، ال لله كككأ و ،لله أرع ، ال للهعأ. ي الأرع كككأ لا تكككالن ت تقكككلله إلككك شكككا ، لكككر الراللهلككك ، كككّ و هككك الكككللهذا كككن ذلكككك فإ ّ ال لله ن الإواةلله التأ تخ الل، العلذأ ح كأ ال كأ ، ع ك كن ال ّ كت خ ، و ك ول ،ن التصو لله ال أ والت ع لله الأص ن. ون ال كواحأ ال كأ ، ر تقا ر ال واحأ التألله خ كأ ولا تت ك ، ي ت ، إنش إا الراللهل والل ،ل أ ليللهع ولا تللهلكا ، اللهي لا ت أ عك ، فأ تهك ال للهحهأ ن الش لله لوى شذاللهي وااش صولله له أك و ن ألن ذ لهو ع ع الصولله ن ذلكك التكالله ّ ي ةذا العح ل ه ، لك ل الأرعأ وال للهي ع ر القللهآن ال لله ا والحر ال عوي الشكلله اك ، أصن تالله ّ الذي ةو عحق ف كك،ن صككرى للهحهككأ ف لله ككأ لله و ّ حتكك حككر التطككو لله أ ، لأ إككا ككولله حءكك ً ،صكك، ككي إللهة ، . أ ال ع ن ، ل ا الإللا وف للهه الإ ل ، العشلله أ ن خلن ت ،هتلّ ت
إبراهيم امحمد محمد السلوقي(1-2016)