Department of Pharmacognasy

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Dr. Muftah A. M. Shushni

د.مفتاح علي الشوشني هو احد اعضاء هيئة التدريس بقسم علم العقاقير بكلية الصيدلة. تحصل على الدكتوراة من دولة ألمانيا 2009.يعمل د.مفتاح الشوشني بجامعة طرابلس كـأستاذ مشارك وله العديد من المنشورات العلمية في مجال تخصصه

Publications

Some of publications in Department of Pharmacognasy

Study of Caffeine Consumption Rate and Concentration in Different Food and Beverages Consumed by Libyan Children

Caffeine is the most commonly used psychoactive substance throughout the world. It is found in coffee, black tea, and chocolate, as it is produced naturally in the beans and leaves of the plants used to manufacture these products. This study aimed to make a survey study among children 2-11 years in some Tripoli, Libya schools to determine caffeine concentration in number of beverages and foods consumed by studied children. About 313 copies of the questionnaire were distributed to students to be filled by their parents. Caffeine was extracted from samples using dichloromethane. Purity of isolated caffeine was estimated by using TLC method.Quantitative analysis of caffeine was performed by using a UV-Visible spectrophotometer. Chocolate biscuits, chocolate cake, cocoa milk and chocolate ice cream were the highest consumed products among the studied children (81%, 79%, 67% and 63% respectively). The highest side effects of caffeine consumption was hyperactivity was the highest side effect in children (76%). Some children also suffered from severe side effects such as panic attack (14%). Naseem ice cream sample showed the highest caffeine content (28 mg/serving) among solid samples.Whereas in the beverages, energy drink samples Red pull, XIR and Shark were 268, 262 and 250 mg/serving respectively. In conclusion, there was excessive consumption of caffeine among the studied group of children and some of them showed side effects and even severe side effects. Variety of tested foods and beverages under the study contained uncontrolled concentrations of caffeine. In addition, chocolate milk (Al Rayhan), contained no caffeine. arabic 15 English 97
Sakina S. Saadawi, Khairi A. Alennabi, AMAL .A ABOALLA AMMAR, , , ٍSuhera Mehemed Abdulsalam Aburawi(9-2019)
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دراسة الكيمياء النباتية لنبات الشيح Phytochemical Investigation of Artemisia Herba Alba Asso (Asteraceae)

نبات الشيح وأسمه العلمي "Artemisia herba alba" يتبع الفصيلة المركبة "Asteraceae" هو نبات حولي عشبي، ذو رائحة عطرية ينمو في شمال أفريقيا بما فيها " ليبيا " ومعظم دول أوروبا وأسيا. الجزء الهوائي من نبات الشيح تم تجميعه من جنوب طرابلس " مدينة ترهونه " في شهر أي النار لعام 2007 إفرنجي. تم ٳستخلاص الجزء الهوائي المطحون "1 كجم " لنبات بواسطة جهاز "Soxhelt apparatus" وذلك تعاقبيا بزيادة القطبية للمذيبات العضوية من الأقل ٳلي الأعلى قطبية " الهكسان العادي، الكلوروفورم تم الميتانول ". ثم تجزئة مستخلص الكلوروفورم لنبات بواسطة العمود الكروماتوغرافي وكروماتوغرافيا الطبقة الرقيقة المجهزة مما ينتج عنها فصل المركب "β-sitosterol" الذي تم التعرف عليه بواسطة " جهاز الرنين المغناطيسي، جهاز تحت الحمراء، جهاز طيف الكتلة " وكذلك بالمقارنة بعينة نموذجية. تم دراسة تاثيرثلاتة أنواع من المستخلص كمضادات حيوية على ثلاثة أنواع من البكتريا سالبة لصبغة الجرام (Escherichia coli-Pseudomonas aeruginosa, and Salmonella spp) ونوع واحد من بكتريا موجبة لصبغة الجرام بالإضافة ٳلى قرص "' Impenem كسلالة مرجعية باستخدام طريقة ٳنتشار القرص وطريقة التركيز المانع الأدنى. أظهرت النتائج أن الاختلاف في قطر المنطقة المانعة يعتمد على نوع البكتريا ونوع المستخلص، يتراوح معدل قطر المنطقة المناعة من 8-12 ملم, 14 -16ملم لمستخلص الكلوروفورم والميتانول كان 6.25 ملغم /مل ضد البكتريا العنقودية بينما كان أعلى تركيز كان 100,50 ملغم /مل ضد الأنواع الأخرى من بكتريا سالبة لصبغة الجرام. Abstract: Artemisia herba Alba Asso. (Asteraceae) is strongly aromatic shrubby perennial that grown in North Africa including Libya, most of Europe and Asia the aerial parts of Artemisia herba Alba Asso. Were collected from the south of Tripoli (Tarhona area) aon January 2007. The powder of aerial parts (1Kg ) were extracted successively with n-hexane chloroform, and methanol by soxhelt apparatus .The crude chloroform extract was subjected to column chromatography and preparative thin layer chromatography resulted isolation of two compounds β- sitosterol and mixture of terpenoids which were not further separated . The structures identification was determined by spectroscopically [H1 -NMR, 2D (COSY, HMBC), Mass spectra], in comparison with an authentic sample of β- sitosterol and Stigmasterol compounds using TLC plate. Disk diffusion and Micro dilution techniques were used to determine the antibacterial activity of (n-hexan, Chloroform, Methanol) extracts of Artemisia herba alba against one species of gram positive strain (Staphylococcus aureus) and three species of gram negative strain (Escherichia coli, Salmonella spp and Pseudomonas aerugenosa ). Imipenem discs was used as reference strain. The zone of inhibition varies depending on bacterial species and type of extract. The average diameter of inhibition zone ranges from 8-12mm, 14-16 mm for chloroform and methanol extract respectively. Chloroform and methanolic extracts were effective against gram-positive strain (Staph. aureus) with the least concentration (MIC = > 6.25), while the higher concentrations (100,50mg lml) was effective against the other gram-negative strains.
عائشة مصطفي اللافي (2009)
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Balticols A-F, new naphthalenone derivatives with antiviral activity, from an ascomycetous fungus

Six new naphthalenone derivatives, balticols A-F and the known metabolite altechromone A were isolated from the AcOEt extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected at the coast of the Greifswalder Bodden, Baltic Sea, Germany. All structures were elucidated on the basis of NMR spectroscopic data and mass spectrometric analyses. The balticols were found to exhibit inhibitory activity against influenza virus A and herpes simplex virus. The most potent antiviral activity was observed for balticol E with an IC(50) value of 0.01 microg/ml against Herpes simplex virus type I. arabic 14 English 83
Muftah A. Shushni, Renate Mentel, Ulrike Lindequist, Rolf Jansen(2-2009)
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