Angiogenesis is a complex physiological process that cannot be treated with single agent therapy. Several edible fungi have been known to encompass bioactive compounds, and are promising sources of multi-component drugs. One such widely consumed edible fungi is Cantharellus cibarius, which has been explored for its biological activities. The present study focused on assessing the anti-angiogenic activity of petroleum ether and ethanol extracts of C. cibarius using chick chorioallantoic membrane (CAM) assay. Both the extracts showed a dose-dependent response which was compared with the anti-angiogenic activity of the positive controls silibinin, and lenalidomide. The extracts were also studied for their lipoxygenase (LOX) inhibitory potential and compared to ascorbic acid as the positive control. The IC50 values of the petroleum ether extract, ethanol extract, and ascorbic acid for LOX inhibition assay were 135.4, 113.1, and 41.5 mg/mL, respectively. Although both the extracts showed similar responses in CAM assay, ethanol extract proved to be more potent in LOX inhibition assay. Finally, the extracts were investigated for their chemical composition using GC-MS. A correlation between LOX inhibition and anti-angiogenic potential was established at the molecular level. A meticulous literature search was carried out to correlate the biochemical composition of the extracts to their anti-angiogenic activity arabic 19 English 119
Sandesh J. Marathe, Abdulla Bashein(1-2021)

ABSTRACT Studying burden of maternal diabetes mellitus on preterm babies is an important step to improve outcomes of these babies. The study was designed to compare morbidity and mortality in preterm babies (28-36 wks) born to `mothers with and without diabetes mellitus (DM). An analytical cross-sectional study was conducted at Al Jala Maternity Hospital, Neonatal Intensive Care Unit (NICU) department; all preterm babies with gestational age (GA) (28-36 wks) were enrolled in the study, from January 1st 2016 to December 31st 2016. The study sample was divided to two groups according to maternal health; preterm infant of diabetic mother (IDM) and preterm non-IDM. The information retrieved and analyzed were; sex, gestational age, birth weight, mode of delivery (MOD), Apgar score at 1st and 5th minute, hypoglycemia, respiratory illness, hyperbilirubinemia, sepsis, major congenital anomalies , length of stay (LOS), and neonatal death. Collected data coded and SPSS software was used for analysis. A total of 378 preterm babies were enrolled in the study period divided into: preterm IDM group 79(20.9%) babies and preterm non-IDM group 299(79.1%) babies. The preterm IDM group had significant high frequency of large for gestational age (LGA) and unexpectedly significantly low frequency in respiratory diseases (P= 0.047), perinatal asphyxia (P=0.021) and neonatal mortality (P=0.007); and no statistical significant difference in rate of hyperbilirubinemia (P= 0.145), congenital anomalies (P= 0.187) and sepsis (P= 0.468). Preterm babies born to diabetic mothers do not appear to be at an excess risk of mortality or early morbidity, except for birth weight for which diabetic mothers need more antenatal care. arabic 29 English 150
Najwa Fituri(10-2018)

Background: The fat extracted from the nut of the African Shea tree (Vitellaria paradoxa) is called Shea butter. It has multiple uses at the local level as it is used in cosmetic products and as a cocoa butter substitute in chocolate industries. It has a high nutritious value and is also a valuable product on the local, national, and international markets, making it the ideal candidate to research and invest in. Aim: This study is a comparative experimental study of the possible burn healing effects between imported South African raw Shea butter and samples in a Libyan market. Method: The control samples were brought from South Africa (Benin traditional markets). A total of 18 different samples were collected from different sale centers in Tripoli, including pharmacies, beauty shops, and spices shops, in addition to one sample brought from Poland. Animal experiment on burn healing effect was carried out on nine male Sprague Dawley (350–400 g) rats aged 6–8 weeks old. After shaving the animal’s dorsum hair, a metal cube was used to create a deep second degree burn wound, and the cube was heated to 100°C for 20 seconds. Medication with Shea butter (control, T1, and T2) was initiated daily for one for these groups by the application of a thin film of the Shea butter samples on the burned areas. On days 1, 3, and 7, the rats were anesthetised and a sample from the burned scar tissue and skin adjacent were evaluated using pathological parameters. Results: The histological study indicates that the use of Shea butter T1 as topical treatment induces an immune response, which enhances the form of the presence of a large number of inflammatory cells in the epidermis and dermis layers. The treatment of burned skin with T2 lasted for 72 hours and it showed slightly significant healing in the normal structure of proliferative granulation tissue with accumulation of fibroblasts and inflammatory cells surrounding the sebaceous glands and hair follicles. Small areas of the epidermis which formed few layers were observed and some hair roots were grown. This was well seen in cases of T1 and T2. Shea butter bought as raw might have a bad effect on burned skin. Conclusion: Shea butter bought as raw might have bad effect on burned skin. On the other hand, the sample from Poland had a therapeutic effect, which was because of the additives such as avocado oil, grape seed oil, and others. arabic 18 English 101
Sakina Salem Mohammed Saadawi, Soad Ali Abdulsalam Treesh, ٍSuhera Mehemed Abdulsalam Aburawi, , , (11-2020)