Background: Management of partially edentulous patients with hard and soft tissue undercuts is complicated, and the use of flexible dentures for these cases offers dual advantages of aesthetics and flexibility. However, research shows a varying preference for flexible dentures among general dental practitioners, prosthodontists, and other dental specialties. Objectives: The aim of this study was to survey the attitude and awareness of a sample of Libyan dental clinicians towards advantages, disadvantages, indications, and contraindications of flexible dentures. Material and methods: A descriptive cross-sectional study was conducted among 250 dentists currently practicing in different cities of Libya. Only 218 dentists responded. Using Google form software, a self-administrable e-questionnaire consisting of thirty-one multiple choice questions with "yes," "no" or "not sure" answers encompassing major aspects of flexible dentures was conducted through an online survey. Results: Out of 250 Libyan dentists to whom the questionnaire was sent, only 218 dentists responded and our results revealed that the respondents were females more than males with a ratio (2:1) and more than half of them were of age group (35-60 years) work in governmental dental practice with more than ten years of experience and 34.9% of them prefer and often offer flexible dentures to their patients. The majority of respondents with a long-term success of the flexible denture were prosthodontists who had more than ten years of experience with a correct response rate of more than 50% of questions that reflected their attitude and knowledge. Conclusions: Despite the fact that flexible dentures are not taught in Libyan universities of dentistry, about more than one-third of respondents prefer and recommend this treatment to their patients, and the long-term success of these prostheses was dependent on clinicians' education and their clinical experience.
Yusra Muftah Saad Elfaidy, Warida Abdalla Elnaihoum, Aseidah Abdullah Elgotrany(4-2022)

This study was primarily conducted to investigate the prevalence of imported malaria in a sample of foreign workers (n-1038) in Tripoli during the period from May 2006 to June 2007. A comprehensive review of malaria epidemiology in Libya in the last two decades was also given. All samples were tested serologically using Malaria Rapid Diagnostic test and then examined using blood film technique. Results showed that only 10 samples (1%) were tested positive for both malaria rapid diagnostic test and blood film. Nine of those infected were identified as Plasmodium falciparum and one as Plasmodium vivax. This study confirms that the prevalence of malaria in legal foreign workers is low and the risk of re-introducing or transmitting malaria in the northern areas of the country is remote. It also gives no good reason for including malaria test among those requested for issuing health certificates to foreign workers. The use of malaria Rapid Diagnostic test for malaria detection in this study was proved to be practical and reliable. Although, the situation of imported malaria in Libya imposes no immediate threat to re-emerging of malaria in the country however, continuous surveillance and monitoring particularly to the southern regions and populations have to be taken in a great consideration. An updated new map of malaria vectors distribution in Libya is urgently needed to be able to outline areas of high risk of malaria transmission.
Fadwa Jamaledden Mustafa Kamel Mahanay, Badereddin Bashir K. Annajar(5-2009)

The most common preparation of tocotrienols is the tocotrienol-rich fraction (TRF). This study aimed to investigate whether TRF induced liver Nrf2 nuclear translocation and influenced the expression of Nrf2-regulated genes. Methods: In the Nrf2 induction study, mice were divided into control, 2000 mg/kg TRF and diethyl maleate treated groups. After acute treatment, mice were sacrificed at specific time points. Liver nuclear extracts were prepared and Nrf2 nuclear translocation was detected through Western blotting. To determine the effect of increasing doses of TRF on the extent of liver nuclear Nrf2 translocation and its implication on the expression levels of several Nrf2-regulated genes, mice were divided into 5 groups (control, 200, 500 and 1000 mg/kg TRF, and butylated hydroxyanisole-treated groups). After 14 days, mice were sacrificed and liver RNA extracted for qPCR assay. Results: 2000 mg/kg TRF administration initiated Nrf2 nuclear translocation within 30 min, reached maximum level around 1 h and dropped to half-maximal levels by 24 h. Incremental doses of TRF resulted in dose-dependent increases in liver Nrf2 nuclear levels, along with concomitant dose-dependent increases in the expressions of Nrf2-regulated genes. Conclusion: TRF activated the liver Nrf2 pathway resulting in increased expression of Nrf2-regulated cytoprotective genes.
Ahmed Elbadri M Atia(9-2020)