The most common preparation of tocotrienols is the tocotrienol-rich fraction (TRF). This study aimed to investigate whether TRF induced liver Nrf2 nuclear translocation and influenced the expression of Nrf2-regulated genes. Methods: In the Nrf2 induction study, mice were divided into control, 2000 mg/kg TRF and diethyl maleate treated groups. After acute treatment, mice were sacrificed at specific time points. Liver nuclear extracts were prepared and Nrf2 nuclear translocation was detected through Western blotting. To determine the effect of increasing doses of TRF on the extent of liver nuclear Nrf2 translocation and its implication on the expression levels of several Nrf2-regulated genes, mice were divided into 5 groups (control, 200, 500 and 1000 mg/kg TRF, and butylated hydroxyanisole-treated groups). After 14 days, mice were sacrificed and liver RNA extracted for qPCR assay. Results: 2000 mg/kg TRF administration initiated Nrf2 nuclear translocation within 30 min, reached maximum level around 1 h and dropped to half-maximal levels by 24 h. Incremental doses of TRF resulted in dose-dependent increases in liver Nrf2 nuclear levels, along with concomitant dose-dependent increases in the expressions of Nrf2-regulated genes. Conclusion: TRF activated the liver Nrf2 pathway resulting in increased expression of Nrf2-regulated cytoprotective genes.
Ahmed Elbadri M Atia(9-2020)

More Please check this summary of your article Test We're testing a new feature which would provide a 1-sentence summary of an article to help others quickly decide if it is relevant for them. We need your help to find out how accurate this automatically generated summary is. This summary is for testing purposes – only you can see it. Summary The adequacy of information given to consumers on over-the-counter medications dispensed in community pharmacies in Tripoli, Libya, and compared the performance Thank you for your help! Your feedback will help improve this feature. Very good How would you summarize your article in 1 sentence? Help us improve the quality of this feature by writing your own summary. Others will not see your summary. Enter your 1-sentence summary (max 300 characters) Do you have any other feedback about this feature? Enter your feedback Submit Abstract and figures Background: Adherence to pharmacy practice guidelines for dispensing medications in pharmacy settings is important to ensure the safe use of medications. Aims: This study assessed the pattern and adequacy of information given to consumers on over-the-counter medications dispensed in community pharmacies in Tripoli, Libya, and compared the performance of pharmacists and non-pharmacists. Methods: This was a cross-sectional survey of private community pharmacies conducted in 2018 . Trained simulated patients were used to collect data on over-the-counter medications dispensed for hypothetical common cold symptoms and the information given by the pharmacy staff on the medication. This information included: name and the strength of the medication, indication for use, duration of use, dosage, how often to take the medicine, timing (before/after/with food), storage, expiry date, and side-effects of the medicine. Time taken to deliver the information was recorded. The adequacy of information provided by the pharmacists and non-pharmacists was compared. Results: A total of 169 pharmacists were surveyed. There were no significant differences between pharmacists and non-pharmacists in information given on the dispensed medications, except for information on taking the medication with food or not (84.5% of pharmacists gave this information versus 57.1% of non-pharmacists; P = 0.001) and on potential side-effects (39.4% of pharmacists versus 20.3% of non-pharmacists; P = 0.014). Significantly more pharmacists (85.9%) than non-pharmacists (61.2%) provided the medication-related information in less than 1 minute (P = 0.001). Conclusion: The inadequate information on medications provided by pharmacists is a concern for patient safety. Health regulatory organizations need to promote safe medication practices.
Ahmed Elbadri M Atia(7-2020)

This study was primarily conducted to investigate the prevalence of imported malaria in a sample of foreign workers (n-1038) in Tripoli during the period from May 2006 to June 2007. A comprehensive review of malaria epidemiology in Libya in the last two decades was also given. All samples were tested serologically using Malaria Rapid Diagnostic test and then examined using blood film technique. Results showed that only 10 samples (1%) were tested positive for both malaria rapid diagnostic test and blood film. Nine of those infected were identified as Plasmodium falciparum and one as Plasmodium vivax. This study confirms that the prevalence of malaria in legal foreign workers is low and the risk of re-introducing or transmitting malaria in the northern areas of the country is remote. It also gives no good reason for including malaria test among those requested for issuing health certificates to foreign workers. The use of malaria Rapid Diagnostic test for malaria detection in this study was proved to be practical and reliable. Although, the situation of imported malaria in Libya imposes no immediate threat to re-emerging of malaria in the country however, continuous surveillance and monitoring particularly to the southern regions and populations have to be taken in a great consideration. An updated new map of malaria vectors distribution in Libya is urgently needed to be able to outline areas of high risk of malaria transmission.
Fadwa Jamaledden Mustafa Kamel Mahanay, Badereddin Bashir K. Annajar(5-2009)