المستودع الرقمي لـجامعة طرابلس

Variant liver oestrogen receptor transcripts in hepatocellular carcinoma are associated with aggressive clinical course and unresponsiveness to tamoxifen. To evaluate the impact on survival and on tumour growth of megestrol (progestin drug acting at post-receptorial level) we enrolled 45 patients with HCC characterized by variant liver oestrogen receptors in a prospective, randomized study with megestrol vs. placebo. Presence of variant oestrogen receptors was determined by RT/PCR. 24 patients were randomized to no treatment and 21 to therapy with megestrol 160 mg day−1. Results were analysed by Kaplan-Meier and Cox methods. Survival of hepatocellular carcinoma characterized by variant oestrogen receptors was extremely poor (median survival 7 months); megestrol significantly improved survival (18 months) (P = 0.0090). Tumour growth at one year was significantly slowed down in megestrol-treated patients (P = 0.0212). Bilirubin levels, presence of portal thrombosis, HBV aetiology and treatment were identified at univariate analysis as factors significantly associated with survival; at multivariate analysis, only megestrol therapy (P = 0.0003), presence of HBV infection (P = 0.0009) and presence of portal vein thrombosis (P = 0.0051) were factors independently related with survival. (1) Megestrol slows down the aggressive tumour growth of patients with hepatocellular carcinoma characterized by variant estrogen receptors and (2) is also able to favourably influence the course of disease, more than doubling median survival. © 2001 Cancer Research Campaignhttp://www.bjcancer.com arabic 12 English 103
A Dugani, Aisha Mohamed Dugani(4-2001)

The incidence of thromboembolic diseases is increasing, and they are a major cause of mortality and morbidity worldwide. Mediterranean diet is known for its high content of olive products, especially olive oil, which has known cardiovascular health benefits, including those on blood pressure, cholesterol level, and thrombogenesis. All previous animal and clinical studies investigating the beneficial antithrombotic effects of olives have focused on olive oil and a few on olive leaves (OLEs). In this study, the ethanolic extract of OLE was evaluated for its antithrombotic activity in the rabbit model of thrombosis induced by ligature of the vena cava and intravenous administration of tissue thromboplastin. Pre-treatment with 100 or 200 mg/kg per day of the ethanolic extract for 8 weeks significantly prolonged the prothrombin time (PT) in comparison to the control group (12.1090.35 sec and 14.3890.29 sec vs. 10.890.32 sec, pB0.05 and 0.001, respectively). In comparison to the control group, the same doses had no statistically significant effect on thrombus weight (16.8590.67 mg, 16.3290.35 mg, and 17.8190.75 mg; p0.18 and 0.06) or on activated partial thromboplastin time (APTT) (19.1790.33 sec, 19.1290.73 sec, and 18.9790.41 sec; p0.36 and 0.43, respectively). One important finding in this study concerns thrombus morphology. In the extract treatment groups, the thrombus was filament-like and did not adhere to blood vessel walls, whereas in the control group the thrombus was thick and almost completely occluded the vein. Therefore, these results suggest that OLE ethanolic extract can modify the extrinsic coagulation pathway as evidenced by the prolongation of PT and changes in thrombus morphology, enough to justify further research to evaluate its possible antithrombotic effects. arabic 20 English 96
AM Dugani(1-2021)

Background: Hyperglycemia and hyperlipidemias are common clinical problem among users of glucocorticoids (GCs). The aim of the present study was to explore the effect of oral administration of the aqueous extract of Abelmoschus esculentus peel (AEPE) on hyperglycemia and hyperlipidemia induced in rats by dexamethasone (DEXA). Methods: Twenty-four rats were randomly divided into four equal groups. Each group was treated for 10 days either with 2% carboxymethylcellulose orally (normal control); 10 mg/kg DEXA subcutaneously (hyperglycemic group); 100 mg/kg AEPE orally plus 10 mg/kg DEXA subcutaneously (treatment group 1); or 200 mg/kg AEPE orally plus 10 mg/kg DEXA subcutaneously (treatment group 2). Animals were killed after 10 days of treatments by decapitation, their blood collected for the analysis of blood sugar and lipid profile. Results: Treatment with DEXA induced a significant increase in blood glucose and all lipids and a significant reduction in body weights. After 10 days of treatment, 100 mg/kg of AEPE was able to significantly reduce the effect of DEXA on triglycerides and low-density lipoprotein (LDL) only. 200 mg/kg of AEPE was able to significantly reduce the effect of DEXA on blood glucose levels, cholesterol, triglycerides, and LDL. Both doses of AEPE were able to increase high-density lipoprotein. Conclusion: This study suggests that the AEPE could be beneficial in protecting against GC-induced hyperglycemia and hyperlipidemia. arabic 18 English 116
Aisha Mohamed Dugani(4-2013)

Warfarin is commonly prescribed as oral anticoagulant medication for Libyan patients, the wide inter-individual variation between the patients in their response to oral anticoagulants is attributed to genetics factors, mainly polymorphisms in CYP2C9 and VKORC1. This study was aimed to assess the impact of genetic (CYP2C9*2, *3 and VKORC1- 1639G>A/ and 1173 C>T polymorphism), and non- genetic factors: age, and body mass index (BMI) in the response of Libyan patients using oral anticoagulants.A total of 100 patients with stable maintenance dose of warfarin or acenocoumarol were recruited during their routine follow up in anticoagulant clinic at Tripoli Medical Centre. CYP2C9 and VKORC1 variant alleles were screened by (HRM) real-time PCR, followed by DNA sequencing.The variant allele frequencies of CYP2C9*2, CYP2C9*3, and VKORC1 -1639G>A/1173C>T were 9.5%, 4.0%, 4.5%, and 37.0%, respectively.Carriers of VKORC1 (-1639 G>A, 1173 C>T) variant alleles required a significantly lower doses of oral anticoagulants compared with carriers of wild type, P value =0.04, and 0.019, respectively. No significant difference in dose requirement was found between carriers of wild type, and CYP2C9*2 and *3 variant alleles, P value =0.11 and 0.98, respectively.The multivariate regression model including age, BMI, VKORC1, and CYP2C9 genotype produced weak model for estimating the drug dosage (R2= 8.6%); and neither genetic nor non-genetic factors could be used as a predictor for estimation of oral anticoagulant dosage.Our data showed that VKORC1 variant alleles but not CYP2C9*2, *3 variant alleles significantly contributed to oral anticoagulant dose variability. arabic 16 English 82
Aisha Mohamed Dugani(7-2019)

Prediction of the present and future state of Reinforced Concrete (RC) structures suffering from chloride-induced corrosion is important if proper planning for inspection and maintenance is to be made. The majority of research studies have thus far focused on the diffusion process of chloride ions through the concrete cover, the time to corrosion initiation and on the prediction of the surface condition of the structure. However; practical evidence and theoretical analysis suggests that many structures can tolerate considerable corrosion damage without serious reduction to their load carrying capacity. Therefore, visual impression-based maintenance is not an optimum solution particularly when financial resources are limited. To support this notion, accurate models are needed to predict the deterioration rate of the structural load carrying capacity over time. This paper uses existing empirical RC deterioration models to predict the loss in the load carrying capacity of a typical RC T-beam using a reliability based approach. The approach takes into consideration the spatial variability of the deterioration parameters, thereby demonstrating the importance of its inclusion in any such analysis. arabic 13 English 97
Omran Kenshel(1-2009)

This paper provides experimentally determined estimates of the scale of fluctuation of the principal variables employed in modeling chloride-induced corrosion for reinforced concrete; i.e., the surface chloride content (Cs) and apparent diffusion coefficient (Dapp). The estimation of the scale of fluctuation, θ, is based on the analysis of experimental data recorded on a bridge in South East Ireland prior to its extensive rehabilitation in 2007. In determining the scale of fluctuation the paper considers two commonly used methods; i.e., the maximum likelihood method and the autocorrelation curve-fitting method. The reliability of both methods is discussed. Introduction of the kriging statistical interpolation method is demonstrated to improve the reliability of the estimates of the scale of fluctuation. The results obtained from the analysis are compared with values in the literature proffered by other researchers. arabic 16 English 119
Omran Kenshel(1-2013)

شملت الدراسة مجموعة من تلاميذ إحدى المدارس الابتدائية في منطقة سوق الجمعة\ طرابلس في الفترة مابين شهري (يناير- فبراير)، وتم استهداف91 عينة تعود لـ 46 تلميذ من الذكور و45 تلميذة من الإناث تراوحت أعمارهم ما بين 7-10 سنوات، وذلك لغرض التعرف على الفطريات المصاحبة لشعر(فروة) الرأس، وتم التعرف على أربعة عشر من الفطريات التي تنتمي إلى تحت الأقسام (Sub Divisions) الآتية: Zygomycotina(1)، Ascomycotina(2)، Deuteromycotina(11)، وكانت أكثر الفطريات شيوعاً عند الأطفال (التلاميذ) هو فطر Candida albicans ( 37.36%) ثم يليه كلاً من فطر P.chrysogenum و A. alternate وCladosporium sp. ( 24.18%) لكل منهم. كان أكثر الفطريات شيوعاً عند الأطفال (التلاميذ) من الإناث فطرA. Alternate (35.56%) يليه فطر P.chrysogenum (26.67%)، بينما في الأطفال (التلاميذ) من الذكور فكان الفطر الأكثر شيوعاً فطر Candida albicans (54.35%) ويليه فطر Cladosporium sp. (30.43%). arabic 80 English 0
هدى ميلاد محمد بن زائد, أمال مصطفي ميلاد انبيه(3-2017)

The aim of this exploratory and empirical case study is to investigate the effectiveness of using classroom observation for developing English language teaching skills among teaching assistants in Libyan Universities- Tripoli University. Four teaching assistants and two experienced teachers were randomly chosen for this study. Data was collected through four phases. Phase one: a closed-ended questionnaire was used to find out the teaching assistants‟ current perceptions of teaching skills. Phase two: the participants were engaged in observing experienced teachers. During the third phase, the participants were involved in teaching to be observed by experienced teachers. In the last phase, teaching assistants‟ perceptions were re-examined through the same close-ended questionnaire and through the observation of experienced teachers. This project is guided by the following research questions: how competent are EFL Libyan Teaching Assistants in undergoing teaching? And how effective is the implementation of Peer Observation in developing those Teaching Assistants?. The findings of this study indicate that classroom observation is a useful technique for developing English language teaching skills. arabic 7 English 47
Hani K. Ertemi(2-2019)